US Secretary of State Rex Tillerson has accused Iran of “alarming ongoing provocations” aimed at destabilising the Middle East and undermining America’s interests in the region.
“An unchecked Iran has the potential to travel the same path as North Korea and to take the world along with it,” Mr Tillerson said.
President Donald Trump earlier ordered a review of the Iran nuclear deal.
However, the US admits that Tehran is complying with the 2015 agreement.
Iran has so far made no public comments on the latest developments.
It has repeatedly denied accusations by the West that it was ever trying to develop nuclear weapons.
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On Tuesday, Washington accused North Korea of trying to “provoke something”, after Pyongyang conducted a failed missile test over the weekend.
North Korea said it may test missiles on a weekly basis, and warned of “all-out war” if the US takes military action.
What is the US doing about Iran?
In a statement on Wednesday, Mr Tillerson said a review, which he had announced in a letter to Congress a day earlier, would look at the whole US policy towards Iran – taking in not only Tehran’s compliance with the nuclear deal but also its actions in the Middle East.
He accused the country of “alarming and ongoing provocations that export terror and violence, destabilising more than one country at a time”.
“Iran is the world’s leading state sponsor of terrorism and is responsible for intensifying multiple conflicts and undermining US interests in countries such as Syria, Yemen, Iraq, and Lebanon, and continuing to support attacks against Israel.”
As part of a long list of charges, he criticised Iran’s involvement in the Syrian conflict and its support for President Bashar al-Assad.
The secretary of state earlier acknowledged the Iranians had met the terms of the 2015 nuclear deal. But he said its “nuclear ambitions” remained “a grave risk to international peace and security”.
What is the Iran nuclear deal?
The landmark 2015 agreement saw crippling sanctions lifted after the International Atomic Energy Agency (IAEA) certified Tehran had restricted its sensitive nuclear activities.
Barack Obama argued the deal, between Iran and six world powers including China, Russia and the UK, was the best way to prevent Iran getting a nuclear weapon.
But President Trump has described the landmark agreement as the “worst deal ever”.
Iran says its nuclear programme is entirely peaceful and that it will continue missile development.
How has the US position changed?
Analysis by BBC State Department correspondent Barbara Plett Usher
In announcing a broad review of Iran policy the Trump administration has not jettisoned the nuclear deal.
But Rex Tillerson has come pretty close to saying the agreement is not worth keeping, even though he’s had to admit it’s working.
This week the secretary of state informed Congress that Tehran is keeping its side of the bargain to restrict its nuclear programme in exchange for the lifting of sanctions, which he’s required to confirm every 90 days.
In spoken remarks, though, he talked only of Iran’s bad behaviour and linked that to the future of the deal – a message that will resonate far more on Capitol Hill and to which it was probably aimed.
Former President Barack Obama would have agreed with all the charges: that Iran is a state sponsor of terrorism, that it supports proxies which undermine US interests in the region, that it’s hostile to Israel and that its ballistic missile tests challenge UN Security Council prohibitions.
But Mr Obama kept those issues separate from the nuclear agreement, which would have been impossible to achieve without that narrow focus.
Mr Tillerson, on the other hand, called this a mistaken approach and said the review would take a comprehensive look at all of the threats posed by Iran.
What has this got to do with North Korea?
President Donald Trump has stepped up US pressure on North Korea, which has accelerated its nuclear and missile tests in recent years, despite international condemnation and UN sanctions.
North Korea’s aim is to be able to put a nuclear warhead on an intercontinental ballistic missile that can reach targets around the world, including the US.
Mr Trump has said that will not happen, and “all options are on the table” in dealing with Pyongyang.
On Wednesday, Mr Tillerson repeated the Trump administration’s view that “strategic patience is a failed approach”.
And he said the US wanted to change course before Iran became a “second piece of evidence” for this.
However, Iran says it has the right to nuclear energy – and stresses that its nuclear programme is for peaceful purposes only.
US accuses Iran of ‘alarming provocations’ amid nuclear tensions}